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Author: Thi Van Anh Tran, Van Minh Nguyen, Duy Hien Tran, Le Thanh Tuyen Nguyen, Thi Hong Tuoi Do, Thi Le Thuy Nguyen, Quang Ngoc Tran, Anh Duy Do, Sang Moo Kim and The Han NguyenIssued date: 11/03/2020
Issued by: Bioscience Research, 2020 17(1): 459-466
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Abstract
The brominated sesquiterpenes were demonstrated to have diverse biological properties both in vitro and in vivo. In this study, three brominated sesquiterpenes including aplysistatin (1), palisadin A (2) and palisadin B (3) from the methanol extract of Vietnamese red alga Laurencia intermedia Yamada were purified and characterized. The antimicrobial activities of the purified sesquiterpenes were determined against human pathogen, shrimp and fish bacterial pathogens. The cytotoxic activities against human liver cancer (Hep-G2), breast cancer (MDA-MB-231) and muscle rhabdomyosarcoma (RD) cell lines were also evaluated. Compounds 1-3 exhibited the antimicrobial activities against Vibrio harveyi and Edwardsiella ictalurid with the MIC values of 250 and 500 µg/mL, respectively. All purified sesquiterpenes 1-3 showed the anticancer activities against Hep-G2 with the IC50 values of 33.98 ± 2.02, 36.70 ± 3.45 and 43.70 ± 7.18 µM, respectively. Only compound 1 exhibited the cytotoxic effects on MDA-MB-231 and RD cell lines, with the IC50 values of 18.86 ± 2.45 and 24.22± 2.21 µM, respectively.
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