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Author: Thi Nhu Quynh Bach, Duc Tuan Cao, Thi Hong Lien Hoang, Anh Duy Do, Mai Anh Nguyen, Thi Quyen Vu, Thi Dao Phi, Thi Hong Minh Le, Thi Mai Huong Doan, Van Cuong Pham, Trong Quan Khong, Quoc Tuan Nguyen, Jung-Woo Chae, Hwi-yeol Yun, Min-Kyun Na, Young-Ho Kim, Van Chuc Dang, Truong Son Nguyen, Van Hung NguyenIssued date: 31/01/2022
Issued by: In: Van Toi V., Nguyen T.H., Long V.B., Huong H.T.T. (eds) 8th International Conference on the Development of Biomedical Engineering in Vietnam. BME 2020. IFMBE Proceedings, vol 85, pp 527-537. Springer, Cham.
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Abstract
Bacterial resistance is getting more and more serious, and Vietnam is one of the high bacterial resistance prevalent countries in the world. Hence, the development of new antimicrobial agents, domestically, is urgently needed. During the course of our screening program, the ethyl acetate extract of a marine-derived fungus strain (Penicillium chrysogenum M612), isolated from sediment collected in Bai Tu Long sea, showed good inhibition activities against tested clinical important microbial pathogens. Subsequent analysis of the extracts prepared from the strain M612’sculturebroth(50L)ledtotheisolationofsevencyclodipeptides.Structureof isolatedcompoundswasdetermined,basedonMS;NMRspectroscopicdataanalysis and compared with literature, as cyclo-(L-Pro-L-Leu) (1), cyclo-(L-Pro-L-Val) (2), cyclo-(L-Ala-L-Pro) (3), cyclo-(L-Pro-L-ILe) (4), cyclo-(L-Pro-L-Phe) (5), cyclo(D-Pro-D-Phe)(6)andcyclo-(L-Pro-L-Tyr)(7).Allthecompoundswerepreviously reported to have antimicrobial activities. The obtained results suggested that strain M612 can be further studied to develop an antimicrobial agent.
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